N,N-Dimethyl-D-ribo-phytosphingosine Modulates Cellular Functions of 1321N1 Astrocytes
نویسندگان
چکیده
منابع مشابه
Dihydroxylation of 2-vinylaziridine: efficient synthesis of D-ribo-phytosphingosine.
An efficient and highly stereoselective synthesis of D-ribo-(2S,3S,4R)-phytosphingosine was accomplished in 62% overall yield starting from commercially available (2S)-hydroxymethylaziridine via osmium-catalyzed asymmetric dihydroxylation as a key step.
متن کاملChemical synthesis of D-ribo-phytosphingosine-1-phosphate, a potential modulator of cellular processes.
d-erythro -Sphingosine-1-phosphate (2), an intermediate in sphingosine metabolism, shows a diversity of biological activities. Comparable roles might be anticipated for d-ribo -phytosphingosine-1-phosphate (1). We describe an efficient three-step chemical synthesis of 1 from d-ribo -phytosphingosine. Our approach is based on standard phosphoramidite methodology and on the finding of Boumendjel ...
متن کاملPreparation of anti-Vicinal Amino Alcohols: Asymmetric Synthesis of d-erythro-Sphinganine, (+)-Spisulosine, and d-ribo-Phytosphingosine
Two variations of the Overman rearrangement have been developed for the highly selective synthesis of anti-vicinal amino alcohol natural products. A MOM ether-directed palladium(II)-catalyzed rearrangement of an allylic trichloroacetimidate was used as the key step for the preparation of the protein kinase C inhibitor D-erythro-sphinganine and the antitumor agent (+)-spisulosine, whereas the Ov...
متن کاملBiosynthesis of Phytosphingosine
Dihydrosphingosine-4,VH was synthesized via the catalytic tritiation of N-carbobenzoxysphingosine. The tritium activities on carbon atoms 4 and 5 were 47 and 37%, respectively; the remainder of 16% on carbon atoms 6 to 18 was due to double bond migration, or carbon-bonded hydrogen exchange, or both. Radiochemical impurities of high specific activity were formed during the synthesis and were det...
متن کاملMeCP2 modulates gene expression pathways in astrocytes
UNLABELLED BACKGROUND Mutations in MECP2 encoding methyl-CpG-binding protein 2 (MeCP2) cause the X-linked neurodevelopmental disorder Rett syndrome. Rett syndrome patients exhibit neurological symptoms that include irregular breathing, impaired mobility, stereotypic hand movements, and loss of speech. MeCP2 protein epigenetically modulates gene expression through genome-wide binding to methy...
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ژورنال
عنوان ژورنال: Biomolecules and Therapeutics
سال: 2007
ISSN: 1976-9148
DOI: 10.4062/biomolther.2007.15.2.073